It all depends on what happens next... which is never a good position to be in when you've already committed to the outcome.
There are some 1.5 million British working and living in Europe. Approximately 900,000 of them are retirees living in Spain. Do they get thrown out, required to pay for health insurance, no longer get cost of living increases to their state pensions? The working British, do they get to stay, or do they also have to come back. Apply for local citizenship?
Trade. One of the more priceless moments in the vote coverage Thursday night was one of the Brexiters saying 'of course, there would still be free trade with Europe - the Germans sell a lot of cars to the UK.' Well, yes, and I'm sure they'll still be happy to sell to the UK, how about buying? Oh the good side is if the pound stays down, exports are cheaper - but England only produces 60% of the food it needs, and that particular bill hits everybody.
Finance. One of the issues lurking in the background is the role of the UK banks in the general debacle that is the world financial system at this time. The Europeans want to regulate the system more, and they particularly want the British to shutdown some of the more blatant exploits being practiced there (Britain is something of a haven for complex financial scam^H^H 'deals'), and also runs some real tax havens. This is the British version of the Trump problem, the people with the money from exploiting the system are now the people with power - it would be really interesting to know exactly what it is that the predominantly upper class supporters of Brexit in the Conservative party want to do that membership of the EU is blocking. But probably nothing good. Then there's the issue with the pound - well I guess everybody who owes money in Sterling will be pleased this week. (btw. if the UK moves to push interest rates up, that's Global Financial crisis 2 there and then.)
Immigration - some of this is an old tradition of 'playing the orange flag' (exploiting ethnic divisions for political gain), some of it is bad economic conditions (due to British Government policies, technological change, and the long running adjustment to the loss of the empire) causing stress . Leaving that aside, there are just as many angrily anti-racist folks in England as there are racists, and judging by newspaper comments over the last few days, they're about to head straight for each other's throats.
Of course, if the immigration issue is taken to its logical conclusion, then Britain swaps ~1,5 million able bodied Europeans, for ~900,000 pensioners and some really pissed off able bodied British, who weren't able to get permanent residency wherever they happened to be living. Scotland may need to thing about that one carefully.
Amongst them, a lot of medical staff in the NHS:
https://www.theguardian.com/society/2014/jan/26/nhs-foreign-...
Now the real issue there, is that the number of medical college places over the last couple of decades hasn't kept up with the population growth and retirement. Since this ought to be one of the easiest possible things to plan, it's a horrible failure, but of the British Government, not of the EU.
London - which is most of the economy these days (another huge issue, but again not the EU's fault), is increasingly integrated into the EU through the tunnel, and as a financial centre - not surprisingly Mayor Khan is already advocating for a special deal for London with the EU.
While the rest of the country hated London, because it dominates the economy, even before the EU split got so exposed - and in fact British government is horribly centralised in London these days, which is a large part of the issue with Scotland. So you can just imagine how well that one is going down.
And underneath all this is the Internet, busily creating the September to end all Septembers, and fast emulating the poor old Babel fish which, "by effectively removing all barriers to communication between different races and cultures, has caused more and bloodier wars than anything else in the history of creation".