Also what are the raw/compressed sizes for a human genome?
I have wondered this for a long time but never seem to find a concrete answer.
Also what are the raw/compressed sizes for a human genome?
I have wondered this for a long time but never seem to find a concrete answer.
A nucleotide is one of [A,T,C,G]. So that means it encodes 2 bits of information.
473 * 1200 * 2 = 1 135 200 bits, or 141.9 kilobyte.
Of course, this is coming from a software developer using numbers from Google, so I might be wildly wrong.
[1] "Molecular biology of the cell" by Bruce Alberts
you can download the human genome from here http://hgdownload.soe.ucsc.edu/goldenPath/hg38/bigZips/hg38.... (it is recommended to use ftp, see: http://hgdownload.soe.ucsc.edu/goldenPath/hg38/bigZips/). it is an ~800mb download.
if it takes 800 mb to store 3.3 billion bases, i would assume it takes (531k / 3.3b) * 800 mb = 0.141 mb to store this genome.
genomic regions with higher variability between individuals are annotated separately and are not represented in the main chromosomal sequence, but can be aligned to it as such.
http://hgdownload.soe.ucsc.edu/goldenPath/venter1/bigZips/
However, the human "reference" genome (the updated main product of the Human Genome Project) is a patchwork of about 20 donors' genomes. Many(most?) of the donors are anonymous volunteers from Buffalo, NY, USA.