It may be true that there are aspects of human nature that can't be disrupted by technology, but the problem is recognising which can and which can't. Often when something fails you don't actually know because it may succeed under slightly different circumstances. The failure of a startup is evidence that there may not be a market for "disrupting human nature" in that domain, but it definitely isn't proof.

This. Absolutely this. Superior software/technology has, is, and will lose to crappy stuff from time to time. And here is why... psychology trumps technology. If your technology doesn't align well with psychology then you have an enormous uphill climb to conquer. If your solution requires people to fight their nature, best of luck to you.