For the last month I've been working on a Flask extension called Flask-Ask I want to plug. The "Ask" part stands for the "Alexa Skills Kit", which is the service behind the Amazon Echo family of devices.
https://github.com/johnwheeler/flask-ask
I've used a lot of web frameworks, and I love Flask! The Alexa Skills Kit is based on its own Request/Response model built in JSON on top of REST, so it made sense to incorporate mitsuhiko's architectural patterns like decorator-based routing, context locals, and templates, and adapt them for Flask-Ask.
I put up a 5-min tutorial for Flask-Ask here:
https://www.youtube.com/watch?v=eC2zi4WIFX0
You can develop without an Echo Device using Amazon's Echosim service: https://echosim.io/
Thanks!