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Agreed. GNU Guix makes it easy for anyone to publish a bunch of package recipes for their own software that users just need to add to their GUIX_PACKAGE_PATH.

The benefit is that it integrates with the rest of the system and thus shares software updates, storage space, and gets overall features such as isolated builds and transactional upgrades and rollback.

Flatpak uses ostree, which is content-addressed, so any identical files are automatically shared.

You can put a single file on a system otherwise not configured with nix (however nice it is). So it's much more universal, and much easier to make inroads into already established infrastructure without having to disrupt it, or even care much about it.

Doesn't it still require flatpak to be installed? I don't see how much different would it be compared to having Nix installed ontop of a distro.

You can install Nix on any Linux system without making it control everything else.