Please, using more CSS selectors than DOMs isn't going to kill a site. In fact, it isn't even close to being a bottleneck. We are talking milliseconds. If you want speed gains, properly compress your images!
Billions, not millions.
Most instructions have not taken over 2 cycles on x86 since P4. This is a mesofact, update your worldview. :)
What you want is a CPU with a short pipeline, a fast clock rate and if possible instruction reordering and multiple dispatch.
Large caches and good branch prediction help a lot too.