I operate a telecom company that mimics the twilio API and we are nabbing their bigger customers left and right. Being fully transparent - our average cost per minute of long-distance is $0.00014 (with 6 second increments) and twilio charges $0.0015/minute (with _60_ second increments).
Wholesale long-distance prices are falling MUCH faster than application providers charging per-call or per-minute. IMHO, That arbitrage will be squeezed eventually as telecom becomes more commoditized.