Fran Allen. In Coders at Work (pp. 501-502):
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-Seibel-: When do you think was the last time that you programmed?
-Allen-: Oh, it was quite a while ago. I kind of stopped when C came out. That was a big blow. We were making so much good progress on optimizations and transformations. We were getting rid of just one nice problem after another. When C came out, at one of the SIGPLAN compiler conferences, there was a debate between Steve Johnson from Bell Labs, who was supporting C, and one of our people, Bill Harrison, who was working on a project that I had at that time supporting automatic optimization.
The nubbin of the debate was Steve's defense of not having to build optimizers anymore because the programmer would take care of it. That it was really a programmer's issue. The motivation for the design of C was three problems they couldn't solve in the high-level languages: One of them was interrupt handling. Another was scheduling resources, taking over the machine and scheduling a process that was in the queue. And a third one was allocating memory. And you couldn't do that from a high-level language. So that was the excuse for C.
-Seibel-: Do you think C is a reasonable language if they had restricted its use to operating-system kernels?
-Allen-: Oh, yeah. That would have been fine. And, in fact, you need to have something like that, something where experts can really fine-tune without big bottlenecks because those are key problems to solve.
By 1960, we had a long list of amazing languages: Lisp, APL, Fortran, COBOL, Algol 60. These are higher-level than C. We have seriously regressed, since C developed. C has destroyed our ability to advance the state of the art in automatic optimization, automatic parallelization, automatic mapping of a high-level language to the machine. This is one of the reasons compilers are... basically not taught much anymore in colleges and universities.
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The assertion that compilers weren't taught any more is just silly.
Allen was specifically discussing auto-optimizations (what we nowadays would just call 'compiler optimizations') and essentially argued that low level languages, in the quest of allowing fine-grained manual optimization, prevent many types of advanced auto-optimizations.
Specifically speaking, it is well known that FORTRAN still often beats C in numerical calculations just by the virtue of not supporting pointer aliasing (especially pointers pointing to arbitrary positions in the middle of an array which is being looped over).
Also, I've seen some of these benefits of Genera in modern stacks but I still don't have all of these capabilities:
http://www.symbolics-dks.com/Genera-why-1.htm
Any jump out at you as particularly awesome for a developer OS?
Intel MPX, CHERI are just two modern approaches of reusing those ideas to tame C's memory issues.
Going back to FPGAs, I think function composition is very similar to digital circuit design, so FP concepts could be a very nice way to do GPGPU programming instead of the actual mainstream approaches. But it would require the GPU to be more FPGAs like.