Pittsburgh doesn't have the crime / corruption problems (largely the same IMO - you can't expect citizens to follow the law if the politicians don't) that Baltimore and Philly do.
Most of the old northern industrial states and cities are so riddled with taxes and regulations and union corruption it's hard sell to start up a business there. You'd be better off carpet-bagging to business friendly locales.
People are moving in large numbers to Florida and Nevada for sound reasons.