I can say the same for Baltimore and Philly. In fact, Pittsburgh is much the same as most cities that used to be the leading innovative areas during the Industrial Revolution and Gilded Age.
Most of the old northern industrial states and cities are so riddled with taxes and regulations and union corruption it's hard sell to start up a business there. You'd be better off carpet-bagging to business friendly locales.
People are moving in large numbers to Florida and Nevada for sound reasons.