Hi, pathology resident here, studying prostate cancer, and apoptosis in particular. This is an interesting study, and I'm glad to have seen it. I submit that growing a line of cells in culture has relatively little the natural progression of those cells in vivo. Indeed, any cell line that can be propogated in definitely ex vivo surely has some funky stuff going on inside. So, if you're inclined to say that we should be skeptical of mouse models, we should be really skeptical of cell lines. For example, the modal number of chromosomes in these cells is something like 85 (normal is 46).

That said, interesting idea. I noted in the methods that the cells were not grown in low-oxygen conditions, and I'm wondering, if the authors are listening, why they didn't do that.