The beauty of AutoCAD was that it was designed for power users only. The learning curve was almost vertical...but to me, that's the true sign of a powerful application. Fortunately, I had a high-school drafting class and then took a class at my local community college...having a real-life instructor was invaluable. It was exclusively designed around a "one hand on keyboard, one hand on mouse" stance, but you could do _everything_ from that position.
Once I got over the the initial learning hump and most of the commands became second nature, I could work almost as fast as I could think. I was working on something like a 500Mhz PIII running Win98, and I cannot remember it ever lagging or crashing while I was working.
But the most important thing to me? Since it was a desktop app, it had 100% control over the keyboard and mouse inputs.
No accidentally closing a tab or refreshing the page.
No browser updates f'ing with my right click menu.
No scroll-jacking.
No zoom-jacking.
No shortcut-key overlap with plugins (looking at you, 1Password/google docs)
No input lag...EVER.
I miss that level of user/machine interface...Every. Single. Day.