The point is that even if there were some yet undiscovered particles or forces, they wouldn't have any effect whatsoever on the world around us. This we can say with certainty. Even if it turns out that our current understanding of QM or GR are just approximations of the real laws of physics, again, this won't matter, much as GR doesn't matter at the speed of a moving car and thus you wouldn't take time dilation into account when you calculate the time you need to get from point A to point B.