> Addicts are going to get fucked up on whatever they can find. If they can't find opiates or whatever, they're going to get fucked up on cough syrup, or booze or huffing paint or whatever.

While this is reminiscent of something Matt Dillon's "shameless dopefiend" character from Drugstore Cowboy said, I'm not sure if this is true.

There is another thread of addiction research that establishes the notion of "addiction as self-medication," in which users seek the drugs that work to alleviate their symptoms, be they physical or psychological. Anecdotally, I've experimented with a lot of substances, and opioids are the only class of compounds that I have sampled that work for me.

In addition, while it's certainly true that, if you attach two acetyl groups to morphine you end up with something 2-3 times more potent by weight, I wonder if people's conception of the "hardness" of drugs is somewhat artificial.