The real thing we care about is "wasted processor cycles", as well as their source. We measure some sources (branch mispredictions, instruction cache thrashing etc.) and some potential sources (e.g. cache misses). What we lack is a metric how bad each instance is. Not every branch misprediction has the same cost. With cache misses the cost can be nearly zero or very high. It would be nice to be able to measure (or simulate or estimate) the real magnitude of each problem.

As long as we don't have that, cache misses are a useful metric on their own, as long as one is aware of its caveats. As most things, cache misses come in various shades of grey.