For example, over 50 million Nintendo Wiis are installed in homes around the world, but nobody is clamoring for "Wiimote" apps at work.
The iPad surely has the potential to change the way casual home users interact with their computers... but I believe pg's comparison to microcomputers in the enterprise is a misplaced analogy.
Paul, if you're reading this, I urge you to spend a few days observing the 'knowledge workers' at a bank, claims processor, hospital, or real estate developer. Watch how they have memorized all the shortcuts and quirks of their custom line-of-business apps. You'll discover a class of users who want power and control, not simplicity and ease-of-use.