Yes. Truckers have to deal with a sort of standard "road safety dilemma" all the time, which can be boiled down to this:
A trucker is driving a 40 ton truck at 65mph. A passenger car with a family of four cuts in front of it, and the distance is closing fast.
A passenger car takes roughly 315 feet to come to a complete stop. A fully loaded truck takes 525 feet. The trucker now has to make a decision.
A) Do I slam on the brakes and keep going straight, and completely obliterate the car in front of me and the family inside it?
B) Do I cut off to the side, running over the rail, flipping the truck, killing myself, and possibly any other vehicles or pedestrians around, behind, or coming in the opposite direction of me?
The robot trucker could of course decide on B), but there are unknown variables about the extent of the resulting damage. This risk increases with merging between lanes or on/off ramps both by passenger vehicles, the truck itself, and motorcycles.
A dedicated lane would make this fantastically safer, but who will pay for it?