I used the site both before the re-design and after.
love the re-design.
Lots of reasons:
-the core of thesixtyone is about discovery and the problem with many discovery sites is they are too bogged down with choices. the browsabilty of the new design is commendable.
-all of the stuff they are clearly doing around machine learning is more obvious in the second version
-the new design is edgy and i'm sure they knew they would alienate some users, but it's also gorgeous. about time artistic content was more aligned with artistic design.
sure, there are definitely a few usability kinks (trying to delete a song from a saved list, for example) but am i confident that they'll fix them eventually? absolutely.