They fought but not with the degree of murderous violence that Europeans had, and native Americans were immediately enslaved, called subhuman, savaged etc and were deliberately exterminated without trying to hide the fact. Like I said I thought it was an exaggeration but having read the book, it changed my perspective on history.
When the first European explorers arrived in South America, there was a massive and advanced civilisation there. Far greater and larger than I ever thought. Massive cities were destroyed, some of them engineering marvels. The enslavement and murder of native Americans continued there for centuries.