Look at the disaster of Long-Term Capital Management from the financial industry as an example, where a presumed ten sigma event almost wiped out the whole western financial system.
http://epicureandealmaker.blogspot.fi/2007/05/11000000000000...
These nuclear reactors are built with the same underlying principles and risk-management profiles. There's always the element of human error; you can't over-engineer something you did not foresee. In addition to that you have the enormous profit incentives from running nuclear power. These incentives can overwhelm the incentives for safety, or lead to disregard of warnings where profit potential would be compromised if warnings were attended to.
It's human, therefore it's hard to ever sleep completely sound knowing that these constructions are running on the planet.
Fukushima didn't just happen because one mistake was made either. It happened because a long string of mistakes and disregard of safety happened. Want to bet it doesn't happen again? It's hard to bet against human nature...