1) First there were the "hashbang" URLs, that Google said they'd crawl fine, but that did affect Gawker's SEO: http://www.webmonkey.com/2011/02/gawker-learns-the-hard-way-...
2) And instagram uses server rendering for SEO: https://twitter.com/cpojer/status/711729444323332096 (via http://jamesknelson.com/universal-react-youre-doing-it-wrong...)