I get tired of installing ad blockers on every machine/device in the house, and on some machines use multiple different browsers -- I'm suffering from blocker installation fatigue.
If you run dnsmasq, you can block [1] a lot of ads for your entire house at once through DNS.
1: https://www.debian-administration.org/article/535/Blocking_a...
Look into setting up a Squid node for your home network and run adblock in the ACL rules.
It's also worth noting that uBlock Origin has a separate redirection framework which includes certain anti-anti-adblock capabilities. uBlock Origin also recently introduced an overlay buster[1] which can work as a generic filter to block the kinds of overlays that the anti-adblockers show.
[1] https://github.com/gorhill/uBlock/commit/ff8f0eb7a9c39e8941f...