Personally, I think (all else being equal) Dota might be an easier starting point than League because of its focus on item abilities, rather than champion abilities. Anybody can use a BKB in Dota, but in League you have Fiora W, Morg E, and a bunch of other things. You have a smaller set of abilities/effects to worry about.
The dodge/aim AI can be situationally good (Cass bots) but still, the best players do win against scripters. Scripters rarely make it into the elite echelons of the ladder; there's a situation right now with a former pro Korean player who started scripting but couldn't make it back into Master tier. You'd expect a former pro with very in-depth game understanding to play at the very tip top level with some 'aim assist' but it doesn't appear to be the case!
Your example of script-users not attaining high ranking in online play for league of legends is also misguided. Because the action space in league is so much smaller than in starcraft, it is much easier to develop an AI with game strategy competency for league. Combine that AI with perfect mechanics, and human players should be falling very readily.
The prevalence of lane swaps (2 go top, 1 goes bottom) in competitive is one major counterexample. In fact, these often turn into having 3 or 4 people in one lane at the start of the game, forcing a fast push strategy.
> Teams will farm with occasional gank attempts until the midgame, where there is a slow transition from farming to objective taking and teamfighting.
Stereotypical Chinese LoL matches are nearly all teamfights, for better or for worse. Regardless, laning and midgame is where I think you should consider my point of champion diversity as well. Here, mistakes can be more readily mechanically exploited (late game, mistakes are punished strategically), e.g. if a laner is far from baron without TP, exploiting a 5v4 fight is a strategic decision, whereas missing certain skills early on in certain matchups means a severely negative outcome if the opposite laner has the mechanics, e.g. no flash and Q on CD as Lux means any Morgana can flash ult for guaranteed kill. These have a bigger impact than racial considerations and probably make up for map considerations (idk)
The script user example is one of mechanics: top players still win against those with pixel perfect scripted mechanics. This is despite having some scripters having 'game strategy competency' (that might be a real thing, but I interpret it as a player having real game knowledge).
IMO the biggest challenge to a human player playing against a team of 5 AI-controlled players is that of communication; perfect understanding of each others' intent is a far cry from the communication of even practiced teams.
Micro and unit control is where the AI has the advantage.