> But frame-by-frame cel animation - which involves weeks, months, years of tedious drawing - has been comprehensively disrupted by upstarts like Anime Studio (http://my.smithmicro.com/anime-studio-pro.html), which uses bones and inverse kinematics to produce quality animations quickly and easily.

I'd hardly say Anime Studio disrupted anything

It's more like 3D suites replaced high end FBF animation, and Flash + Toon Boom replaced low end FBF animation