Unless, of course, they've been geotagging their tweets from a mobile device. In which case it would then be trivial to look at their most frequent location, determine it's a residential one, wait until they're out, and head on over.
Which is why I will never enable Twitter geotagging.
Chances are it's not that rare to be able to get an address for someone that's connected enough to be tweeting their location all the time.
Also, in addition to “empty home” you also want a place where no-one hears you if you break a window or similar, a place where it is easy to leave with the stolen goods without being noticed, and a place that has stuff worth stealing.
Given the variables, were I a professional thief, I would scout for locations first, then find out when the residents were not at home second, which is probably fairly simple even without the use of Twitter.
People are no where near as isolated as they'd like to believe.