I've been using JSX since React 0.4. React's greatest strength is its simplicity. You can read all of React's documentation in 20 minutes. There's hardly any learning curve compared to the larger JS frameworks out there. It's all just JS*--no "logic-less-ish-kinda-sorta" template for loops, or two way data bindings, or figuring out when to render.
I don't think JSX is the terrible problem the hyperscript people make it out to be, but I think it might be time for it to retire. While JSX is as mild as learning curves come, it's still a learning curve. It still requires transpilation. It requires the extra characters. To reframe the conversation, does it make sense for the learning curve to be "it's HTML-ish with caveats like camelcasing but it works like JS" or "it's a collection of functions that generate HTML that are named for the HTML tag they generate."
I'm also really interested in the "but it makes sense to designers" argument. Is that actually true? Are there designers out there who understand JSX but wouldn't understand well formatted hyperscript? I feel like that's saying "yah I get ERB but HAML doesn't make any sense."
Again, I don't think this is a big enough deal for the amount of attention it gets paid. I'd love to see the React team bring in first class hyperscript-like syntax that is 100% JS, but it's hardly a reason to not use React.