If I had to guess (and this is pure speculation), AlphaGo has no concept of waiting for its opponent to make a mistake. Instead, it assumes its opponent will continue to make the best possible follow-ups, and so AlphaGo feels overly compelled to "keep up". In this case, that did it in.
If this is what happened, then yes, I would expect Lee to be able to capitalize.
This has also resulted in larger shifts in playing style over time. Studying very old (and I mean very old...700+ years old) games can be entertaining and even educational in the abstract, but you won't want to directly adopt the style of play because the game has evolved.
It's already been mentioned a couple of times that AlphaGo almost certainly represents just such a shift. Top players will learn from it, and I'd even be willing to bet they will beat it with some regularity once they do!
Ultimately, what sets apart Go geniuses is their ability to play creatively in the face of seemingly insurmountable challenges. So the big question is how "creative" AlphaGo can be. Is it merely synthesizing strong play from known positions? Can it introduce novel strategies? And if it does, will it be able to adjust as other Go masters adjust to it and bring their own brand of creativity to play?
To answer your original question, this very well could introduce a new era of more aggressive play to the world of Go. Only time will tell...
This incarnation of AI is not creative, it wont generate new play styles, that is still the domain of top human players for now. But it will ruthlessly learn and adopt any new and improved strategies. That's really the point to take away from its success so far.
The OMG-AI people claim that AGI would be dangerous because it would reliably innovate in new spaces and out-predict humans.
So a true super-AGI would make go moves that were unexpected and incomprehensible with some percentage of misleading fake-outs, but it would still win most or all of the time.
If the human exploration of Go-Space is close to the god's hand bounds, this can't be true.
We'll know if this is the case in a couple of years, if the competition between human and AI goes back-and-forth (unlike Chess, where after AI was good enough to beat humans, it could do so reliably).
Either way, it's interesting to note that AlphaGo had literally thousands of games to learn from to find weaknesses in human play, but Lee Sedol seems to have only needed 3 before he was able to find weaknesses in AlphaGo's play.
To be fair we can't know how many games Sodol played in his own head to figure this out.
But they're already working on a new version of AlphaGo which isn't trained on any human data at all. It starts by making truly random moves and improves from there. This will require much more processing time and probably an order of magnitude more "self-play", but it will probably result in truly novel strategies that aren't part of the current human metagame.
One of the DeepMind guys just confirmed that this is how AlphaGo operates in the press conference.
-- Pyanfar Chanur (C.J. Cherryh)