The article's conclusion would indicate that you would do use in-silico biology to 'discover' existing drugs. Then once computer methods can reliably discover, say both penicillin and tetracycline, you'd push forward.

Funding this, however, would never come from industry. You'd need to convince NIH that spending many years rediscovering old drugs is the magic leap forward we need.

As someone ignorant of the field - has this been done? What is the state of validation in computer biology?