It looks like a neat experiment (definitely cool though), but I imagine you could (eventually?) implement a scripting language like lua in it, and register your program's external commands the scripting language needs access to.
(The project is very cool! The instruction set reminds me a bit of the MIPS subset usually implemented in uni courses.)
I haven't decided on audio. It might be a set of sys calls that manipulate oscillators. The graphics interface is quite literally just manipulating the program memory. You can see the registers in the lower left corner of the video I linked.