I'm in Pittsburgh until I leave... the biotech community mostly consists of UPMC but they have a huge presence in the town. There are some medical device startups here but the lack of angel/VC funding minimizes the startup presence.
Housing is very cheap here; it's one of the few housing markets in the country with the peculiar property that a monthly mortgage payment would be less than rent on an equivalent house. I wouldn't recommend raising a family in Oakland, which is turning into a student ghetto all over, but Squirrel Hill's a good neighborhood.
There's a whole lot of topography and global warming has made our winters a little better.