Network (which really means just keep in touch with folks you have worked with or met).
At your current employment situation, keep your ear to the ground. You don't need to move to a big company (they have layoffs too) but you want to be aware of what is happening.
Ask your boss questions about the business, and do your own research too. If your company is "default dead" then ask how you can help make it "default alive".
Cut your unneeded expenses.
Start a company if you have the drive to so, don't worry about the macroeconomic climate.
Source: reading, living through the 2000 and 2008 recessions as a developer.