No. In the past I've tried several times to create a lightweight Debian derivative that would still allow me to install Debian/ubuntu packages from their repositories. The smallest I've been able to get things without completely breaking everything was around 230mb. This required lots of ugly hacks such as post install triggers that would remove useless garbage such as /usr/share/doc/ and man pages.
It's simply not possible to take the Debian eco-system and magically turn it into a slim version of itself.
I would never run Alpine stand-alone on a server. But for containers, it's absolutely amazing. I don't need the full Debian ecosystem. All I need is some basic tools such as NPM, Pip or gem. They can take care of the rest. The whole point of containers is to escape from the dependency and package hell that we're currently in.