For a startup like mine, I already estimate I'm installing hundreds of libraries (Ruby gems, Python wheels, etc). I'm pretty sure some of them are weird dependencies... but I have come to trust apt and dnf.
There is zero reason for me to trust Alpine's new package manager that is managed by a single dev. Disk space is cheap - my time is not.
This is the big blocker - if Alpine can figure out a way to co-exist with apt or dnf (pick your own poison), that makes it compelling.
But then again, I would ask - can something like Alpine be achieved with debian or centos. Even if it is 3X the size (30mb) ?
EDIT: I run a fat docker VM based on debian with nginx, rsyslog, postgresql and ruby+puma using supervisord. There is absolutely ZERO need for OpenRC. I have been running this in production for over 18 months since before Docker was this stable.