If on the other hand you are looking for a number that is_prime says is prime, and you are iterating through candidates, you need to know how likely it is to find a prime number in the first place to tell you how unlikely this is. In most cases the chance of a false positive will be much, much higher than 2^-80.
If for example, you only expected to find a true prime in 1 every 2^80 numbers anyway, there would be a 50% chance that a number you found is prime and a 50% chance it would not actually be.