+1 for YC Research's basic income (and standard for quality of life)

Meta-Research. +1 for @mietek's Meta-research; creating a distributed, open ecosystem (not a website, but a protocol) for publishing and navigating interdisciplinary research.

Medicine. +1 for Bacteriophages @mietek & open-medicine (e.g. Counter Culture Labs - Open Insulin) https://experiment.com/projects/open-insulin. Additionally, cancer and heart disease research.

A distributed, persistent, interoperable world wide web. (e.g. IPFS)

A sensible distributed DOI and identity system for people.

A meta exploration to determine the world's hard problems and impending catastrophies (e.g. www.metaculus.com)

Alternative energy and renewable energy.