What any individual, or even large group of human minds, can achieve is a very tiny fraction of what can be achieved given enough time and scale. And if that isn't nihilistic enough, it probably means absolutely nothing given even more time.

So, no, I think that fear is a silly byproduct of our own biases with or without the possibility of superior intelligence.

I'm sure when the AI overlords really take over, they'll give you a little box for you to excel in :)