> I'm talking about Microsoft, Uber, Amazon etc... the ones who have literally changed the way people live.
...or they road a wave...
You didn't mention Walmart. ;-)
Uber has had a number of competitors, back in their day when they were "changing the world", so did Microsoft & Amazon. Hell, Microsoft's operating system ride started with an operating system they bought from someone else.
If you grow at a crazy fast rate to become a household name, you inherently are riding some kind of wave change. I don't think that was what the MIT Microfluidics PhD friend was referring to as "novel". If you want to call that "novel", then you are going to have a much harder time making the case that Theranos isn't trying to be novel.