It's hard to quantify happiness or flourishing or whatever we define as the ultimate goal.
That said, it's quite clear that infant mortality, occasional starvation or death from minor infections and other paleolithic norms are not a benefit to whatever we define as the ultimate human goals. It's equally clear (regardless of quantification) that obesity, depression and suicide rates, loneliness, impostor syndrome and other features of 21st century life are not of benefit to us either.
I'm fairly sympathetic to the view that if you moved people into a "natural" setting for a few weeks or months where they gather food, live in close contact with natural cycles like daylight and weather and expose their bodies to the stresses of such a lifestyle, than many of these modern pathologies dissipate. I've experienced this (like many people report) when camping or trekking even for a few days. I am also inclined to accept (in a general way with few absolutes and much room for exceptions) the hypothesis that this is an evolutionary heritage.
Look Brother jacquesm… I agree that people get overblown with their health ideology and that it can get silly. We don't really want to be paleo or even know how. But, it's based on ideas that are interesting, appealing, and not nonsensical. So what if people get a little overexcited about them. You should listen to me when I get into a good futurism conversation. Your friend is looking for a way to live better and her approach is sensible. We also need a couple of puritans and extremists among us, as long as they're harmless. Someone needs to bear a flag and find out where the logical limits of some idea is, like Richard Stalman does for Free Software..
TLDR, sometimes we (people) get a little carried away with theory. But overall, these paleo ideas are nice ideas. They're intelligent, reasoning about ourselves as evolved beings and actively working to alleviate some of the ills. It's way more interesting (and sane) than most things people get passionate about. Ever visit HN when open vs private offices gets discussed?