Stopping them from directly hitting our routers has been the most difficult, because our routers have IPs on 1000+ /24's, which means RTBH can't work because no tier 1 will accept 1000+ null routes. The same is true when they attack our upstream provider's networks.
We've had a few false-starts, but we've finally gotten all of our datacenters dropping all traffic to these critical IPs at the edges. This should stop the most serious outages, so it's a big step.