Is it not possible for some big philanthropists like Gates, Buffett etc to buy some of these drugs and release the patent so others can manufacture cheaply? What is stopping them from doing it?
Take Gilead for example, which created Harvoni/Sovaldi for treating Hep-C. It's currently valued at about $150B. Before the release, it was a quarter of the price, so the value of Gilead's Hep-C franchise is in the order of $70-$80B at the very least. That's about the entire net worth of Bill Gates.