For example only: Stop Forum Spam only recently began testing their work for IPv6: https://www.stopforumspam.com/forum/viewtopic.php?pid=44371
I re-wrote my comment spam solution (not specifically for the comment spam problem, was doing some other stuff) and have long since enabled IPv6, but it's worth bearing in mind that network is one thing, sometimes what holds someone back from flipping the switch are the tools we use.
https://support.cloudflare.com/hc/en-us/articles/202494830-P...
So when 2001:db8:a1:b2::c:3 has sent spam to you, you can't know if you should block the network 2001:db8:a1:b2::/64 or the specific address 2001:db8:a1:b2::c:3. Some blacklists (carelessly) take the former approach and block entire datacenters.