Exactly. Definitely not enough research taking a harm reduction approach. There's quite a bit of short term research on a lot of things that give some basic insights, but don't add additional variables that are useful even if adding them isn't particularly difficult. Long term studies are obviously harder, but for prescription amphetamines which have been around for a while, you'd think we'd have some decent research on the long term effects on cognition. But nope, there's way more research on long term cognitive effects of cocaine than amphetamines. And even that research doesn't seem to focus on harm reduction and best practices.