1. Our use of CFCs caused global ozone depletion: https://en.wikipedia.org/wiki/Ozone_depletion#Antarctic_ozon...
2. Our use of leaded gas caused global lead poisoning: https://en.wikipedia.org/wiki/Tetraethyllead#History_of_cont...
2. That one is grossly exaggerated to force people buy some gasoline products. There are local impacts on local human populations, but this is not a global problem and can never be. Total area of all cities and motorways is just 0,5% of land. Everything humanity built on this planet is negligibly small if properly scaled.
Here is what can do a real climate change, for example (and it did). Cyanobacteria long time ago consumed most of "greenhouse" gases from our precious atmosphere and produced oxygen is such quantities that massively extinct themselves, leaving some nice fossils still visible in Australia. Humanity is not even close to that scale of activity.