Proxy ads through software on the actual webserver; make them part of the markup like any other page element. Ingest the Apache access logs. Use website-level cookies and relay them to the ad network on the server side. Etc.
>One, AdNauseam, clicks every ad on every page I visit
Wired would like you do install addons that click on every ad on wired.com.
Part time blocking can create even more focused profiles Poisoning the well is better if you aren't willing to or can't commit to 100% blocking.
Obfuscating snoopers' profiles is more satisfying.
Continuesly bringing people that are totally off te chart in re to our vertical (due to someone fooling system of their true interests) would bring down ROI to near-zero and have us stop using said Publisher althogether.
Genius move!