No. What you described will work for a simple substitution cypher, but not for a one time pad. A one time pad is the same length as the message, and permutates every letter independently. Trying all keys will yield every possible plaintext. For example the phrase:

"The swallow flies at midnight"

May (with a one time pad) be encrypted into

"WD4oXOl8yO0QtD4sOf7ip0P7ScIia"

(which, incidentally, is indistinguishable from random noise)

If you just bruteforced that by xor'ing every character with every other possible character you could derive every possible message of that length, such as:

"garfield hate lasagna someday"

"men are cats why even bother?"

"pocket knives go to space yay"

etc ad infinitum

No measure of semantic analysis will help you here!