For me, and what I took away from this article (confirmation bias), it is that a huge barrier to working remotely is the social and personal identity we implicitly associate with work.

The loosening of tribalism from your job (which between 20-40 could be your main "tribe") may be the root cause of the sense of isolation/loneliness.

I wonder if it's as much the emergence of meetups & co-working spaces rather than the online tools (Slack, Speak, Trello etc) which will grow the remote workforce.