* There are only 250 Duane Reade's total (according to Wikipedia), there can't possibly be 400 in Manhattan.
* Duane Reade as a chain is intricately associated with the city of New York, at least from the point of view of a San Franciscan. It is the local culture.
* What's wrong with not having to walk a mile to go to a drug store? Having more locations helps build smaller neighborhoods.
Nobody grows up wanting to own and operate their own drug store anymore. So chains do it instead.
And I don't see how this is different than 50 people opening their own boutiques and destroying neighborhoods through gentrification. But I'm guessing the author would have a different opinion on that.
also: this is the CEO of kickstarter? Isn't it slightly self-serving for him to say "people should be trying their own crazy things that they could never get money for before kickstarter"?