Adblock Edge was discontinued a little while back but had effectively replaced the not-fully-blocking Adblock Plus of recent months. ABE's UI integration broke in another recent FF update, but the blocking itself continued to work usefully until FF42, at which point apparently it ceased doing anything useful at all.
uBlock Origin is apparently now the blessed alternative and is OK for blocking most ads, but I immediately found a few potential tracking issues with its default lists, and its UI is awful.
Ghostery also isn't blocking various trackers effectively now, even though its UI still claims it has detected and blocked them. I can't 100% guarantee that's FF42 if Ghostery also updated its lists at almost exactly the same time, but that's when I saw things like Facebook Connect start hitting FB servers even though it's supposedly blocked.
This is almost a brand new machine, BTW, which just happened to update FF and lead to changes in the plug-ins a few days after initial set-up. There's relatively little chance of odd things going on or historical baggage distorting these results.
Bottom line: The day I bought the machine and installed FF and my usual set up add-ons, my browsing experience was fine, and then a few days later FF updated to 42, and my browsing experience immediately sucked.