In Cork, big pharma (Pfizer, GSK, Johnson&Johnson) & some tech, Apple, EMC, Vmware, Amazon, Redhat.
Hard to say why the sudden progressive turn in Irish politics. With the marriage equality referendum 1 in 3 voted against, so there is still 33% of the country that I can guarantee you would be very conservative. But yes, for what was once a deeply religious country there has been a seismic shift in culture.
GenX is the generation where the shift first happened. I have seen the following reasons. Television (I'm not kidding), low-cost travel (Ryanair), 3rd-level education, Church scandals, ...
Very hard to say why this political shift, frankly even though people in Ireland have been talking for years about the decriminalisation of cannabis (t the very least) and even though I felt it must happen some day I am still surprised. The supervised injection clinics is a great idea.