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There's quite a few programs like this, and I've tried them all. What makes this look promising is the peeps behind Cyberduck fame are creating it. I always wanted that feature in Cyberduck, where you can mount any arbitrary legacy file system. All the others I've tried are half-baked attempts and horribly buggy.

I am a happy customer of ExpanDrive (http://www.expandrive.com/) which is very similar, except that it is cross platform and looks like it support more back-ends.

ExpandDrive recently greatly enhanced their product by providing background uploads.

Cyberduck (and apparently Mtn. Duck, judging by the screenshots) is equally cross-platform; which is to say, runs on recent-ish versions of OSX and Windows. Expandrive looks decent, but for my purposes fuse is good enough, and free.

Transmit can also do this: https://panic.com/transmit/

I'd assume this is some form of iSCSI or SMB/samba?